Route53 is not a bad option. If you're using EdgeCast CDN as well you'll probably get a discount on DNS (and I will point out that the EdgeCast CDN is faster, and more importantly, a hell of a lot cheaper than Cloudfront is).

For my use cases, CloudFront beat out EdgeCast quite a bit in price. (~20 TB / month commit with a request mix heavily biased towards NA and Europe).

@nieksand, feel free to get in touch with us at speedyrails.com (EdgeCast's resellers), I'm sure we can offer you a much better price than CloudFront's

Dnsmadeasy is also a good option for small to medium size requirements, in my opinion. I use it for my personal domains.